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CommentsAdditional drug/s should be given with this drug to treat patients with susceptible strains of tuberculosisMalabsorption syndrome may occur in patients who adhere to treatment but fail to appropriately respondand may be present in patients with concurrent HIV infectionTherapeutic drug monitoring should be considered in patients with malabsorption syndromeThe duration of treatment should be based on clinical responseincluding permanent bacteriological conversion and maximal clinical improvementThe American Academy of PediatricsAAPrecommends once a day treatment with isoniazidrifampinand pyrazinamide for 2 months in patients with meningitis caused by M tuberculosisand once a day treatment with isoniazid and rifampin for 9 to 12 months in patients with meningitis caused by Mycoplasma bovis.

A second-line antitubercular agent that inhibits mycolic acid synthesisIt also may be used for treatment of leprosyFrom Smith and ReynardTextbook of Pharmacology1992p868)

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